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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.
A MyMyelomaTeam Member asked a question 💭
West Monroe, LA
January 11, 2025
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A MyMyelomaTeam Member

Mm attacks every part of your body that’s why I’m glad I always took vitamins for every part especially my heart!
Cornzyme 10 or the more absorbable form ubiquinol is number one on my list

January 11, 2025
MyMyelomaTeam

Myeloma itself does not directly damage arteries leading to the heart, but it can contribute to cardiovascular disease in other ways. Myeloma often causes high calcium levels (hypercalcemia), which can lead to arrhythmia, and kidney failure, which increases heart disease risk. Additionally, some myeloma treatments, like Show Full Answer

Myeloma itself does not directly damage arteries leading to the heart, but it can contribute to cardiovascular disease in other ways. Myeloma often causes high calcium levels (hypercalcemia), which can lead to arrhythmia, and kidney failure, which increases heart disease risk. Additionally, some myeloma treatments, like chemotherapy or proteasome inhibitors, can cause heart-related side effects, including hypertension and heart failure. Regular monitoring is essential.

January 11, 2025
A MyMyelomaTeam Member

Kyprolis side effects are
Cardiac Toxicities
* New onset or worsening of pre-existing cardiac failure (e.g., congestive heart failure, pulmonary edema, decreased ejection fraction), cardiomyopathy, myocardial ischemia, and myocardial infarction including fatalities have occurred following administration of KYPROLIS®. Some events occurred in patients with normal baseline ventricular function. Death due to cardiac arrest has occurred within one day of administration.
* Monitor patients for signs or symptoms of cardiac failure or ischemia. Evaluate promptly if cardiac toxicity is suspected. Withhold KYPROLIS® for Grade 3 or 4 cardiac adverse reactions until recovery, and consider whether to restart at 1 dose level reduction based on a benefit/risk assessment.
* While adequate hydration is required prior to each dose in Cycle 1, monitor all patients for evidence of volume overload, especially patients at risk for cardiac failure. Adjust total fluid intake as clinically appropriate.
* For patients ≥ 75 years, the risk of cardiac failure is increased. Patients with New York Heart Association Class III and IV heart failure, recent myocardial infarction, conduction abnormalities, angina, or arrhythmias may be at greater risk for cardiac • complications and should have a comprehensive medical assessment prior to starting treatment with KYPROLIS® and remain under close follow-up with fluid management.
Acute Renal Failure
* Cases of acute renal failure, including some fatal renal failure events, and renal insufficiency (including renal failure) have occurred. Acute renal failure was reported more frequently in patients with advanced relapsed and refractory multiple myeloma who received KYPROLIS® monotherapy. Monitor renal function with regular measurement of the serum creatinine and/or estimated creatinine clearance. Reduce or withhold dose as appropriate.
Tumor Lysis Syndrome
* Cases of Tumor Lysis Syndrome (TLS), including fatal outcomes, have occurred. Patients with a high tumor burden should be considered at greater risk for TLS. Adequate hydration is required prior to each dose in Cycle 1, and in subsequent cycles as needed. Consider uric acid lowering drugs in patients at risk for TLS. Monitor for evidence of TLS during treatment and manage promptly, and withhold until resolved.
Pulmonary Toxicity
* Acute Respiratory Distress Syndrome (ARDS), acute respiratory failure, and acute diffuse infiltrative pulmonary disease such as pneumonitis and interstitial lung disease have occurred. Some events have been fatal. In the event of drug-induced pulmonary toxicity, discontinue KYPROLIS®.
Pulmonary Hypertension
* Pulmonary arterial hypertension (PAH) was reported. Evaluate with cardiac imaging and/or other tests as indicated. Withhold KYPROLIS® for PAH until resolved or returned to baseline and consider whether to restart based on a benefit/risk assessment.
Dyspnea
* Dyspnea was reported in patients treated with KYPROLIS®.

July 2, 2025
A MyMyelomaTeam Member

MM and Amyloidosis of the heart is common.
Paula🌹

June 10, 2025
A MyMyelomaTeam Member

Good information. I think it's a good idea for us all to be monitoring our blood pressure and pulse at home.

June 9, 2025

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