Multiple myeloma is incurable, and fundamental biological insights remain lacking in this disease," said John Chute, MD, director of the Division of Hematology and Cellular Therapy at Cedars-Sinai Cancer and senior author of the study. "Our evidence suggests the importance of the reverse signaling pathway of ephrin B2 in regulating multiple myeloma development and progression, and that inhibiting this signal in a targeted way abolishes multiple myeloma growth."
Corresponding clinical data… read more