I take 30mg Duluxetine twice a day. morning and night.It definitely helps without drowsiness. I tried Gabapentin it was too strong for me. So maintaining with what I know works right now. 🙏🏾😊

Hi Sandra, I take Lyrica, 600 mg a day. It keeps me from going crazy with burning feet and tingly hands☹️. I’m maintaining!

I was taking 600mg 2x/day and it wasn't helping to relieve the tingling in my left thumb, forefinger and middle finger. NP now occasionally occurring in my right hand now.
I am going to have my oncologist test for M protein next visit. Last time it was checked it was very low and no problem.
I'm on Darzalex, a monoclonal antibody and the results are just outstanding. My numbers are the best that they have ever been. I've been on chemotherapy for 10 years now (and I'm starting to get "chemo brain" which is a major concern for me) NP has always been an unresolved issue for me. I won't give up Darzalex for anything else like Revlimed.
Velcade stopped working for me after they switched me to the injection versus the IV. They wanted to switch me to injection for Darzalex and I refused to switch based on my experience with the Velcade switch from IV which was working albeit not as well as Darzalex.
I printed this article and will discuss it on my next monthly visit.

Great advice Dennis💕

I started out with just numb feet. I know from early on that if one has the Lambda variety of MGUS, they are much more likely to have PN. I had al the tests for it. The neurologist was of no help to symptoms unless I wanted to take meds with side effects, which I did not.

I started reading and decided to change my diet to an "anti-inflammatory" diet - no sugar, no caffeine, little salt, and eat good veggies, fruits, and some low-fat dairy. I am happy with the diet, and it's much healthier for me in many ways. I also incorporated some low-inflammatory/anti-oxidant-fighting supplements. R-Alpha Lipoic Acid, PEA, Curcumin/Turmeric, L-Carnitine, Vitamins E, C, D3, Omega 3 Fish Oil, garlic, ginger, and EVOO on salads and in food 2-3 tbsp. a day.

I have done that for a year now. My MGUS Mspike has gone from .9 to .2, and all my other MGUS blood tests (Free Light Chains, ratio, etc.) have significantly improved (I am now very low risk). My other blood tests - from lipids (my doctor is amazed at how great my cholesterol is, LDL, triglycerides, and HDL are), to all the other things doctors look at for people over the age of 60-70 especially. My weight is very normal also. Blood pressure 108/66. Not eating red meat (I eat fish and white meat chicken broiled weekly) and adding the veggies and fruit options was an easy switch. I don't miss sugar at all, either. I can do without the caffeine and also the sugar as well.

My symptoms - burning feet, tingling, sharp pains, etc. are 60-70% better. The most I ever take is a Tylenol or two if I've been on my feet a lot. I have flat feet, which worsens things, but I wear compression socks and very good shoes with orthotic inserts. So, if you want to help yourself a great deal, help new nerve growth, and protect existing healthy nerves from damage, you might consider the diet and changes I made. It is worth it for the people who change. People with gluten sensitivities can cut out gluten and get good benefits. It's very similar to a diabetic diet or a "Mediterranean Diet." YouTube and online articles show what is good to eat and what is NOT good to eat if you have PN. Many hematologists/oncologists who are holistically minded and who read up on new treatments also recommend this kind of diet to their MGUS patients, with and without PN. The nice thing is that it helps both.