I'm on dara, Revlimid, and dex. Dara monthly, Revlimid 21 days , 7 off. When I started in 2020 the dara was weekly, Revlimid 25 mg, dex 20mg. I plunged into remission in two months. I had some awful muscle spasms, which lessened as my dosages lowered. My current dosages are Revlimid 10 mg, and dex 12 mg (weekly). I also receive monthly injections of Neulasta. I take loratidine (Claritin) daily, partly for allergies and partly to combat spasms, which can be side effects of Revlimid, dexamethasone, or Neulasta. My key numbers have been "so low as to be almost immeasurable" according to my hematologist at Mayo.

I was on darzalex velcade Revlimid and Dex 20 mg prior to transplant it brought my numbers way down . Now at day 57 since transplant tired fatigued but feeling better

There’s also methlyprednisolone at one fifth the strength of Dex but it may not be strong enough for the Induction phase. I was on it for a short period during maintenance but after 6 weeks I chose to discontinue it. No help and a few problems.

Hi Donna - No sure yet. I think they were in tandem. She went to a hospital in Kansas and stayed 3 months for her initial treatment. Returned to her home in Virginia to receive routine treatment from my Doc. We spoke for 45 minutes the other day to get to know a bit of each other’s story. From what I gathered, she not on any meds for many years and just gets annual checkups. I asked if she knew if her immune levels are normal - she guesses they are and plans to look up older Labs. I met with my Doc a few days ago and asked if my immune levels will return to normal now that I’m off meds - he doesn’t think so. It makes me wonder if the newer meds like Velcade and Revlimid are permanently destroying the immune system. I hope to learn a lot talking with her. She speaks at events about her experience to help others with MM. She hopes to learn plenty from me - we’re at both ends of the spectrum. I’ve been fortunate to seek out and use the latest meds and testing methods and I’ve questioned the “standard of care” to my benefit. My nurse is 30 years in oncology with my Doc. She felt she was advising me with my best interest in mind (to get my SCT now) but my choice to postpone gave Darz the time it needed to finish what it started. Also the three studies I read said C3 Curcumin (4g - 8g) was effective at killing MM. I’ve taken 4gram C3 Curcumin daily once I was diagnosed last Oct.