Wendym, Yes it can, Treatments can change Your Myeloma Type. Your chromosomal abnormalities can also change. Cells are constantly replicating and changing. Love, Marcia 🌼🌸🌻

M-spike is how much protein is in your blood. You are not supposed to have protein in your blood.

I would certainly ask your doctor what those readings mean and what their significance is. I wondered about my M-spike, which nosedived after 2 months of chemo but was still not zero. My oncologist said that they would watch for patterns. Luckily, mine has remained low.

I have also heard of that happening...Even the MM specialist mentioned it before...

Wendym, Not sure its the same as yours, however I was diagnosed as IgA kappa and this past February my IgA Kappa is ok but I have a .20 IgG ? Asked both transplant dr and my oncologists and they said it was a clone? I'm still not comfortable about it but my numbers are stable for now. Still on maintenance Revlimid 10mgs 21/7. Maybe its our bodies going through healing changes? Just keeping a close eye.