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Real members of MyMyelomaTeam have posted questions and answers that support our community guidelines, and should not be taken as medical advice. Looking for the latest medically reviewed content by doctors and experts? Visit our resource section.

Can Someone Explain To Me Why Targeted Therapy To Treat Cancer Is Not Turning Out To Be The Panacea I Once Thought It Could Be?

A MyMyelomaTeam Member asked a question 💭
New York, NY
April 13
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A MyMyelomaTeam Member

I'm still in the process of educating myself when it comes to the different proteins/molecules that certain cells express, so bear with me if my terminology is off. I thought all myeloma cells express BCMA, and that if a drug existed that targets BCMA, well, problem solved.

After typing this, I just found the following.

https://www.mdanderson.org/cancerwise/your-ques....

From the link: "BCMA is highly expressed — or highly shown — on the surface of myeloma cells. That makes it also a very attractive drug target, so there have been several clinical trials looking at drugs that target BCMA."

Maybe something encouraging?

Your questions about BCMA and multiple myeloma, answered
Your questions about BCMA and multiple myeloma, answered
April 14 (edited)
A MyMyelomaTeam Member

My BCMA is almost at the high end. Not good. MM is too complex even for the doctors. I’ve been studying everything I can about it since diagnosis in 2020. A doctor could not even explain to basic to you in a hour.

April 14
A MyMyelomaTeam Member

A lot of the drugs target CD 38 (Cluster of Differentiation). I have CD138, and they don’t have a drug that targets this specific one. I have many other CD’s. They can’t target them all.

April 14

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