Myeloma diagnosis goes by what is called the CRAB criteria. High calcium, Renal issues, Anemia, bone lesions. Usually greater than 60% myeloma cells in the bone marrow. Otherwise it could be something else, like MGUS. Which means there is an elevated m protein, but no other symptoms. Smoldering usually does become active myeloma, MGUS not necessarily

There are a variety of symptoms. I had anemia, low white cells, low platelets. Bone lesion on my ribs. Frequent infections, pneumonia.

I had possible MGUS 7 years ago, diagnosed when I was treated for severe pneumonia. The oncologists cut me loose after about a year of quarterly blood testing, nothing was getting worse. I developed a lung nodule 2 years ago, wouldn't go away. A pulmonogist referred me to an immunologist who order tests showing a very wonked immune system, elevated proteins, etc. An oncologist ordered more blood tests and a bone marrow biopsy, showing elevated plasma cells. I'm diagnosed with Asymptomatic Myeloma. I've been lucky, haven't been struck down by infections nor had bone issues, just fatigue. Many with Asymptomatic Myeloma and MGUS are the same.

My sister had a lot of pain in her side and chest wall.

Anemic